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KMID : 0613820130230070947
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Journal of Life Science
2013 Volume.23 No. 7 p.947 ~ p.954
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Protein Kinases Involved in the Regulation of Wnt/β-catenin Signaling
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Shin Eun-Young
Park Edmond Changkyun
Hong Yeon-hee
Kim Gun-Hwa
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Abstract
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The Wnt/β-catenin signaling pathway is an evolutionarily conserved signaling network that is critical for embryonic development and adult tissue maintenance. In addition, aberrant activation of Wnt/β-catenin signaling is implicated in the formation of various human diseases, including cancers. Thus, study of the underlying molecular mechanism of Wnt/β-catenin signaling regulation is important to understand and treat diseases. Inhibition of aberrant Wnt pathway activity in cancer cell lines efficiently blocks their growth, highlighting the great potential of therapeutics designed to achieve this in cancer patients. Recently, protein kinases have emerged as key regulating components of Wnt/β-catenin signaling. In this review, we provide the most recent information on Wnt/β-catenin signaling, describe protein kinases involved in Wnt/β-catenin signaling, and discuss their potential as drug targets.
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KEYWORD
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Wnt, β-catenin, kinase, cancer, development
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